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Phases of eukaryotic cell cycle, mitosis and meiosis; Regulation of cell cycle- checkpoints, role of protein kinases.
Key experiments establishing-The Central Dogma (Adaptor hypothesis and discovery of mRNA template), Genetic code (deciphering & salient features)
Split genes-concept of introns and exons, removal of introns, spliceosome machinery, splicing pathways, group I and group II intron splicing, alternative splicing eukaryotic mRNA processing (5’ cap, 3’ polyA tail); Ribozymes; RNA editing and mRNA transport.
Study of the following through photographs: Assembly of Spliceosome machinery; Splicing mechanism in group I & group II introns; Ribozyme and Alternative splicing.
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